AnyConnect 4.10.05 does not support the latest TLS 1.3 standards nor the newest cryptographic cipher suites. If you have upgraded your ASA or Firepower headend to a modern code stream, you may experience:

It is critical to note that Cisco has announced the End-of-Life (EoL) for the AnyConnect 4.x series. As of Q4 2024, 4.10.05 is in the Security Maintenance Phase.

Cisco strongly urges migration to AnyConnect 5.x (e.g., 5.1.x). However, 5.x drops support for Windows 7 and macOS 10.15. Therefore, 4.10.05 remains the "last good version" for organizations with legacy hardware.

One of the most common support tickets involves OS compatibility. Here is the definitive guide for 4.10.05:

| Operating System | Minimum Version | Maximum Version | Status | | :--- | :--- | :--- | :--- | | Windows | 7 (SP1 with SHA-2 support) | Windows 11 22H2 | Full Support | | macOS | 10.15 (Catalina) | 13 (Ventura) | Full Support | | Linux (64-bit) | Ubuntu 18.04 / RHEL 7 | Ubuntu 22.04 / RHEL 9 | Limited Support | | iOS/iPadOS | 13.0 | 16.x | Via App Store (separate) | | Android | 8.0 (Oreo) | 13 | Via Play Store (separate) |

Deprecation Warning: This version is the last Cisco AnyConnect release to officially support Windows 7 and Windows Server 2008 R2. Windows 8.0 is not supported.

Symptom: VPN connects but no traffic routes; ping works but HTTP fails. MTU black hole.
Workaround: Reduce MTU to 1300 via registry or ASA group-policy: group-policy DfltGrpPolicy attributes vpn-settings mtu 1300.

A critical component of AnyConnect is the Host Scan engine, which checks the endpoint to see if it meets corporate security policies (e.g., "Is the firewall on?"). 4.10.05 includes updates to the Host Scan library definitions, allowing it to more accurately detect newer versions of third-party security software, preventing false negatives that might block a legitimate user from logging in.

Cisco AnyConnect Secure Mobility Client 4.10.05 is a software client that enables remote users to establish secure VPN connections to Cisco ASA (Adaptive Security Appliance) and Cisco Firepower Threat Defense (FTD) headends. Unlike legacy SSL VPN clients (like the old Cisco VPN Client), AnyConnect is modular, persistent, and supports a "network visibility" paradigm.

The version number 4.10.05 (often denoted as 4.10.05145 or similar build variants) belongs to the 4.10.x release train. This branch is notable because it serves as a bridge release—it supports legacy Windows 7 and Windows Server 2008 R2 (extended support) while also paving the way for Windows 11 and macOS Ventura compatibility.

Symptom: Split tunneling incorrectly routes local subnet traffic through VPN.
Fix: Edit /opt/cisco/anyconnect/profile/YourProfile.xml → ensure <ExcludeTraffic> is not enabled. Restart vpnagentd.

msiexec /i anyconnect-win-4.10.05085-webdeploy-k9.msi /quiet /norestart /lv* c:\temp\anyconnect_install.log

To remove previous versions cleanly before install:

msiexec /x GUID-PREVIOUS-VERSION /quiet