Corrupted shaders are like bad blood; you need to drain them.

For NVIDIA Users:

For AMD Users:

RE2 runs more stable on DX11 for many users. Here’s how to force it:

Sometimes the error is caused by a saved configuration file that is trying to force the game to run at a resolution or refresh rate your monitor doesn't support.


The game engine has a buggy handshake with high-refresh monitors (144hz, 240hz). You need to force a sync manually.