S Gastrointestinal And Liver Disease 12th Edition -
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S Gastrointestinal And Liver Disease 12th Edition -

Often referred to simply as Sleisenger and Fordtran’s, the 12th edition remains the definitive, encyclopedic reference for physicians, fellows, and residents in gastroenterology and hepatology. Published in 2020 by Elsevier, this two-volume set continues the legacy of providing comprehensive, evidence-based, and clinically actionable information on the entire spectrum of digestive disorders. The 12th edition arrives at a time of rapid advancements in gut microbiome research, immunotherapy for liver disease, and minimally invasive endoscopic techniques, all of which are thoroughly integrated into this update.

To enhance learning and retention, the 12th edition includes:


"The 12th edition finally gives equal weight to hepatology and luminal GI. The MASLD chapter alone is worth the purchase price." — Dr. Anna F., Transplant Hepatologist, Mayo Clinic s gastrointestinal and liver disease 12th edition

"I passed my GI boards on the first try using the 11th edition question book. Now the 12th edition’s updated algorithms and videos are a game-changer for my clinical practice." — Dr. Marcus T., General Gastroenterologist, private practice

"The microbiota and immunotherapy sections are the most current I've seen in any textbook. This is not a rehash; it's a true update." — Dr. Lina K., Assistant Professor of Medicine, UCSF Often referred to simply as Sleisenger and Fordtran’s

The Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 12th Edition is available in multiple formats:

Review Question Book: Do not confuse the main textbook with Sleisenger and Fordtran's Gastrointestinal and Liver Disease Review, 12th Edition (sold separately). The review book contains over 1,000 board-style questions with detailed rationales—essential for exam preparation. "The 12th edition finally gives equal weight to

  • Colorectal Cancer Screening (new: mt-sDNA, blood-based assays, AI-assisted colonoscopy)
  • Autoimmune Liver Disease (AIH, PBC, PSC) – new: obeticholic acid, fibrates for PBC
  • Vascular Liver Disorders (Budd-Chiari, PVT, TIPS updates)
  • Hepatocellular Carcinoma (new: atezolizumab-bevacizumab, durvalumab-tremelimumab)
  • Acute Liver Failure & Critical Care Hepatology
  • Liver Transplantation (updated: machine perfusion, frailty assessment, HCV donor to HCV- recipient)
  • While previous editions touched on the microbiome, the 12th edition dedicates multiple chapters to its translational impact. You will learn about: